{"product_id":"a-practical-guide-to-rational-drug-design-9780081000984","title":"A Practical Guide to Rational Drug Design","description":"\u003cp\u003e • Author(s): Sun Hongmao\u003cbr\u003e • Publisher: Woodhead Publishing\u003cbr\u003e • Publisher Imprint: Woodhead Publishing\u003cbr\u003e • BISAC: Industries - Pharmaceutical \u0026amp; Biotechnology\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. \u003ci\u003eA Practical Guide to Rational Drug Design\u003c\/i\u003e focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.\u003c\/p\u003e","brand":"Woodhead Publishing","offers":[{"title":"Hardcover","offer_id":45310323753111,"sku":"9780081000984","price":12002.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9780081000984.webp?v=1769287613","url":"https:\/\/atlanticbooks.com\/products\/a-practical-guide-to-rational-drug-design-9780081000984","provider":"Atlantic Books","version":"1.0","type":"link"}