{"product_id":"adjuvant-chemotherapy-of-breast-cancer-papers-presented-at-the-2nd-international-conference-on-adjuvant-chemotherapy-of-breast-cancer-kantonsspital-9783642823596","title":"Adjuvant Chemotherapy of Breast Cancer: Papers Presented at the 2nd International Conference on Adjuvant Chemotherapy of Breast Cancer, Kantonsspital","description":"\u003cp\u003e • Author(s): Hans-Jörg Senn\u003cbr\u003e • Publisher: Springer\u003cbr\u003e • Publisher Imprint: Springer\u003cbr\u003e • BISAC: General\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eH.-J. Senn Adjuvant Chemotherapy (ACT) of breast cancer has now emerged as one of the controversial su): \u0026gt;jects in clinical and also experimental oncology. Driven by growing frustration about stagnating cure rates in breast cancer [1,4] and stimulated by elegant demonstration of highly curative effects of adjuvant systemic therapy in animal models [6, 11] and in several childhood neoplasias [15], researchers introduced ACT to the primary treatment of breast cancer with great hope some 15 years ago. After a first wave of isolated \"historic\" trials with generally limited but in one case remarkable success [5, 9], a second generation of ACT studies was initiated by NSABP investigators and oncology centers in Europe [2, 6, 13]. These trials were well conducted statistically and diagnostically, and all in the early 1970s included a surgical control arm. Early and intermediate beneficial effects on relapse-free survival (RFS) after 2-3 years median observation time then prompted a whole series of ACT studies in breast cancer. These \"third-gener- ation\" studies usually regarded some positive influence of ACT as a given fact, dropping surgical control regimens and comparing different ACT regimens, hopefully in a prospective, randomized way 1984 Fig. 1. The mushrooming of adjuvant studies in breast cancer XII Introduction [reviews in 3, 14]. The \"mushrooming\" of ACT studies in breast cancer during the last 10 and especially 5 years is demonstrated in Fig. 1, and it gets really cumbersome even for the insider to keep on top of the multitude of sometimes conflicting data.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Paperback","offer_id":45282437693591,"sku":"9783642823596","price":7345.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9783642823596.webp?v=1769302147","url":"https:\/\/atlanticbooks.com\/products\/adjuvant-chemotherapy-of-breast-cancer-papers-presented-at-the-2nd-international-conference-on-adjuvant-chemotherapy-of-breast-cancer-kantonsspital-9783642823596","provider":"Atlantic Books","version":"1.0","type":"link"}