{"product_id":"bace-lead-target-for-orchestrated-therapy-of-alzheimers-disease-9780470293423","title":"Bace: Lead Target for Orchestrated Therapy of Alzheimer's Disease","description":"\u003cp\u003e • Author(s): Varghese John\u003cbr\u003e • Publisher: Wiley\u003cbr\u003e • Publisher Imprint: Wiley\u003cbr\u003e • BISAC: Geriatrics\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBACE inhibitors and their use in the treatment of Alzheimer's Disease\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. \u003ci\u003eBACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease\u003c\/i\u003e covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery.\u003c\/p\u003e \u003cp\u003eThis book details the story of the discovery of BACE and its role in AD and comprehensively discusses:\u003c\/p\u003e  *The development of BACE inhibitors as therapeutics for Alzheimer's disease *The research that led to the identification of BACE *New BACE inhibitors currently being clinically tested *ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature *Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery *Other approaches to BACE inhibition based on interaction with the precursor protein APP  \u003cp\u003eBy enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Hardcover","offer_id":45202247843991,"sku":"9780470293423","price":12342.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9780470293423.webp?v=1767307696","url":"https:\/\/atlanticbooks.com\/products\/bace-lead-target-for-orchestrated-therapy-of-alzheimers-disease-9780470293423","provider":"Atlantic Books","version":"1.0","type":"link"}