{"product_id":"computational-approaches-to-protein-dynamics-from-quantum-to-coarse-grained-methods-9781466561571","title":"Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods","description":"\u003cp\u003e • Author(s): Monika Fuxreiter\u003cbr\u003e • Publisher: Taylor \u0026amp; Francis\u003cbr\u003e • Publisher Imprint: CRC Press\u003cbr\u003e • BISAC: Life Sciences - Biology\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cem\u003eThe Latest Developments on the Role of Dynamics in Protein Functions\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eComputational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods\u003c\/strong\u003e presents modern biomolecular computational techniques that address protein flexibility\/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles.\u003c\/p\u003e\u003cp\u003eThe book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues: \u003c\/p\u003e\u003cul\u003e \u003cli\u003e\u003cem\u003eIs there a quantitative relationship between enzymatic catalysis and protein dynamics?\u003c\/em\u003e\u003c\/li\u003e \u003cli\u003e\u003cem\u003eWhich are the functionally relevant motions of proteins?\u003c\/em\u003e\u003c\/li\u003e \u003cli\u003e\u003cem\u003eHow can structural properties and partner recognition mechanisms of IDPs be simulated?\u003c\/em\u003e\u003c\/li\u003e \u003cli\u003e\u003cem\u003eHow can we speed up molecular dynamics? \u003c\/em\u003e\u003c\/li\u003e \u003cli\u003e\u003cem\u003eHow can we describe conformational ensembles by the synergistic effort of computations and experiments?\u003c\/em\u003e\u003c\/li\u003e \u003c\/ul\u003e\u003cp\u003eWhile dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure-function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.\u003c\/p\u003e","brand":"Taylor \u0026 Francis","offers":[{"title":"Hardcover","offer_id":45236880048279,"sku":"9781466561571","price":18433.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9781466561571.webp?v=1769214834","url":"https:\/\/atlanticbooks.com\/products\/computational-approaches-to-protein-dynamics-from-quantum-to-coarse-grained-methods-9781466561571","provider":"Atlantic Books","version":"1.0","type":"link"}