{"product_id":"cytochrome-p450-in-vitro-methods-and-protocols-9781071615447","title":"Cytochrome P450: In Vitro Methods and Protocols","description":"\u003cp\u003e • Author(s): Zhengyin Yan\u003cbr\u003e • Publisher: Springer\u003cbr\u003e • Publisher Imprint: Humana\u003cbr\u003e • BISAC: Pharmacology\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFrom the Back Cover\u003c\/b\u003e\u003cbr\u003eThis collection explores detailed experimental protocols necessary for setting up a variety of \u003ci\u003ein vitro\u003c\/i\u003e cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the \u003ci\u003eMethods in Pharmacology and Toxicology\u003c\/i\u003e series, chapters include helpful background information on the \u003ci\u003ein vitro\u003c\/i\u003e assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. \u003cbr\u003eAuthoritative and practical, \u003ci\u003eCytochrome P450: In Vitro Methods and Protocols\u003c\/i\u003e serves as a key guide for researchers in the area of discovery and development of new medicines.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Paperback","offer_id":45279644844183,"sku":"9781071615447","price":8732.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9781071615447.webp?v=1769294153","url":"https:\/\/atlanticbooks.com\/products\/cytochrome-p450-in-vitro-methods-and-protocols-9781071615447","provider":"Atlantic Books","version":"1.0","type":"link"}