{"product_id":"drosophila-melanogaster-biosensors-of-atmospheric-oxidative-stress-9783639130621","title":"Drosophila Melanogaster - Biosensors of Atmospheric Oxidative Stress","description":"\u003cp\u003e • Author(s): Malinda Wilson\u003cbr\u003e • Publisher: VDM Verlag\u003cbr\u003e • Publisher Imprint: VDM Verlag\u003cbr\u003e • BISAC: Life Sciences - Biochemistry\u003c\/p\u003e\u003cp\u003eStudies of Drosophila melanogaster have led to molecular insights concerning biomolecular mechanisms of biology and disease including development, differentiation, cancer and aging. Wild-type Drosophila, unlike vertebrate mammals, selectively retains gamma-tocopherol over alpha- tocopherol. Urate-deficient Drosophila compared to wild-type had similar levels of glutathione but only 50% of the ascorbate levels. Dietary supplementation with ascorbate dramatically increased its level while chemically-defined diets led to rapid depletion of ascorbate in both strains. It is concluded that Drosophila do not synthesize ascorbate, and in this respect are similar to humans. Wild-type and urate-deficient Drosophila were continuously exposed to ozone. Exposure of Drosophila to 2 ppm ozone\/24hrs\/day unmasked a marked sensitivity phenotype of urate-deficient Drosophila. Studies revealed that ascorbate supplementation decreased ozone-induced toxicity in Drosophila. Collectively, these data reveal the usefulness of Drosophila as a model organism for studying micronutrient antioxidants and their interrelationship with ozone-induced toxicity.\u003c\/p\u003e","brand":"VDM Verlag","offers":[{"title":"Paperback","offer_id":47610368426135,"sku":"9783639130621","price":4519.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9783639130621.webp?v=1775064487","url":"https:\/\/atlanticbooks.com\/products\/drosophila-melanogaster-biosensors-of-atmospheric-oxidative-stress-9783639130621","provider":"Atlantic Books","version":"1.0","type":"link"}