{"product_id":"group-sequential-and-adaptive-methods-for-clinical-trials-9781584888475","title":"Group Sequential and Adaptive Methods for Clinical Trials","description":"\u003cp\u003e • Author(s): Christopher Jennison | Bruce W. Turnbull\u003cbr\u003e • Publisher: CRC Press\u003cbr\u003e • Publisher Imprint: Chapman and Hall\/CRC\u003cbr\u003e • BISAC: Probability \u0026amp; Statistics - General\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn clinical trials, monitoring accumulating data at regular intervals is essential for balancing ethical and financial considerations against scientific rigor. This comprehensive second edition reflects the remarkable evolution in adaptive clinical trial methodology over the past two decades. Since publication of the first edition, these approaches have transformed from theoretical concepts to widely accepted practices, now endorsed by regulatory authorities, including formal FDA guidance.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFeatures\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e \u003cli\u003eEleven entirely new chapters, including optimal design construction, delayed \"pipeline\" data accommodation, and multiple comparison procedures\u003c\/li\u003e \u003cli\u003eEight dedicated chapters on adaptive methods including sample size re-assessment, seamless Phase II\/III trials, multi-arm multi-stage trials, and enrichment designs\u003c\/li\u003e \u003cli\u003eExact methods for binary and Poisson data with applications to vaccine trials\u003c\/li\u003e \u003cli\u003eExpanded discussion of binding versus non-binding futility boundaries for enhanced decision-making\u003c\/li\u003e \u003cli\u003eA chapter with a thoroughly updated review of Bayesian approaches to sequential trial design and analysis\u003c\/li\u003e \u003cli\u003eIncorporates response-adaptive treatment assignment in group sequential designs\u003c\/li\u003e \u003cli\u003ePractical computational methods and software guidance for implementing the techniques\u003c\/li\u003e \u003c\/ul\u003e\u003cp\u003eThis definitive resource serves statisticians, clinical researchers, pharmaceutical scientists, and regulatory professionals involved in clinical trial design and analysis. The text balances theoretical foundations with practical implementation guidance, making it invaluable for both experienced practitioners and those new to adaptive trial methodology. With twice the content of the first edition, \u003cstrong\u003eGroup Sequential and Adaptive Methods for Clinical Trials, Second Edition \u003c\/strong\u003eprovides the comprehensive understanding needed to design more efficient, ethical, and scientifically rigorous clinical trials, ultimately accelerating the delivery of effective treatments to patients.\u003c\/p\u003e","brand":"CRC Press","offers":[{"title":"Hardcover","offer_id":46931821232279,"sku":"9781584888475","price":7457.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9781584888475.webp?v=1771616392","url":"https:\/\/atlanticbooks.com\/products\/group-sequential-and-adaptive-methods-for-clinical-trials-9781584888475","provider":"Atlantic Books","version":"1.0","type":"link"}