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I peccati dei geni by Manoush Tohidi Rad

I peccati dei geni

by Manoush Tohidi Rad , Mahya Fatahi , Shahin Asadi
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Book cover type: Paperback
  • ISBN13: 9786208097554
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 64
  • Original Price: GBP 30.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 105 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

Oggi il cancro al seno è il tumore più comune tra le donne ed è responsabile del 25% di tutti i tumori femminili. La telomerasi è un bersaglio terapeutico antitumorale appropriato perché è presente in oltre il 90% dei tumori umani, compreso più del 95% dei tumori al seno, mentre nella maggior parte delle cellule somatiche non è rilevabile. La proteina hTERT è un componente del complesso della telomerasi che limita il tasso di attività, quindi l'espressione del gene hTERT all'interno delle cellule è essenziale per l'attivazione della telomerasi. I miRNA sono un gruppo di piccoli RNA non codificanti di lunghezza compresa tra 25 e 19 nucleotidi che svolgono un ruolo chiave come regolatori dell'espressione genica. Nel complesso, tuttavia, si ritiene che la genetica sia la causa primaria del 5-10% di tutti i casi.Le donne la cui madre è stata diagnosticata prima dei 50 anni hanno un rischio aumentato di 1,7 e quelle la cui madre è stata diagnosticata all'età di 50 anni o dopo hanno un rischio aumentato di 1,4. In coloro che hanno zero, uno o due parenti affetti, il rischio di cancro al seno prima degli 80 anni è del 7,8%, 13,3% e 21,1%, con una mortalità successiva per la malattia rispettivamente del 2,3%, 4,2% e 7,6%.

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