{"product_id":"imaging-in-cns-drug-discovery-and-development-implications-for-disease-and-therapy-9781441901330","title":"Imaging in CNS Drug Discovery and Development: Implications for Disease and Therapy","description":"\u003cp\u003e • Author(s): David Borsook\u003cbr\u003e • Publisher: Springer\u003cbr\u003e • Publisher Imprint: Springer\u003cbr\u003e • BISAC: Pharmacology\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFrom the Back Cover\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eImaging is a key area of translational research that provides a unique bridge from the laboratory to the clinic as the same techniques and technologies can applied across the various phases of drug development. Neuroimaging is now central to research and drug development in the neurosciences since it can be used to detect the pharmacological and physiological consequences of drug action within the living brain. Today neuroimaging is used primarily as a biomarker to help optimize our decision-making processes. Neuroimaging tools and technologies can be used to select drug candidates, confirm they engage their targets, link occupancy to biology and then, in a translational fashion, be used to help design the best clinical studies that truly test therapeutic hypotheses.\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eTopics covered include: \u003c\/p\u003e \u003cul\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eThe role of imaging in drug development\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eImaging approaches including structural, functional, molecular and chemical imaging\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eImaging drug action including neuroreceptor mapping to examine drug occupancy characteristics, the involvement of specific neurotransmitter systems in CNS diseases and mechanisms of action\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eFunctional mapping to provide pharmacodynamic evidence of central activity, \"CNS fingerprinting\" of the neuroanatomy of drug effects and disease drug interactions \u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eImaging disease states in preclinical and clinical domains\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eNeuroimaging today is all about the need to identify the best molecules, doses and hypotheses to advance into later stage long term extensive clinical trials that can often be confounded by high placebo response rates. Better decision making in early development allows resources to be focused on the drug candidates and therapeutic hypotheses that have the highest probability of success so that we can bring medical advances to patients as quickly as possible. \u003cem\u003eImaging in \u003cstrong\u003eCNS\u003c\/strong\u003e Drug Discovery and Development\u003c\/em\u003e was written by a group of preeminent international experts in the field of imaging.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Hardcover","offer_id":45274534838423,"sku":"9781441901330","price":10900.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9781441901330.webp?v=1769280212","url":"https:\/\/atlanticbooks.com\/products\/imaging-in-cns-drug-discovery-and-development-implications-for-disease-and-therapy-9781441901330","provider":"Atlantic Books","version":"1.0","type":"link"}