{"product_id":"multinuclear-pyrazolate-based-copper-complexes-inspired-by-the-cuz-site-of-n2o-reductases-9783869559780","title":"Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases","description":"\u003cp\u003e • Author(s): Vera Konstanzer\u003cbr\u003e • Publisher: Cuvillier\u003cbr\u003e • Publisher Imprint: Cuvillier\u003cbr\u003e • BISAC: Chemistry - General\u003c\/p\u003e\u003cp\u003eEnzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site. In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated.\u003c\/p\u003e","brand":"Cuvillier","offers":[{"title":"Paperback","offer_id":47891224133783,"sku":"9783869559780","price":3126.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9783869559780.webp?v=1781182741","url":"https:\/\/atlanticbooks.com\/products\/multinuclear-pyrazolate-based-copper-complexes-inspired-by-the-cuz-site-of-n2o-reductases-9783869559780","provider":"Atlantic Books","version":"1.0","type":"link"}