{"product_id":"natural-resistance-to-tumors-and-viruses-9783642680717","title":"Natural Resistance to Tumors and Viruses","description":"\u003cp\u003e • Author(s): O. Haller\u003cbr\u003e • Publisher: Springer\u003cbr\u003e • Publisher Imprint: Springer\u003cbr\u003e • BISAC: Immunology\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eNatural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma- lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon- strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com- mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de- fense in host resistance against both viruses and tumors. It is evi- dent that considerable variation in the relative importance of di- stinct mechanisms may be found among various resistance sy- stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro- priately complex effector mechanisms. Instances, however, whe- re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru- ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media- tor. The present volume provides insight into current concepts of such resistance mechanisms.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Paperback","offer_id":45280583418007,"sku":"9783642680717","price":3672.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9783642680717.webp?v=1769296731","url":"https:\/\/atlanticbooks.com\/products\/natural-resistance-to-tumors-and-viruses-9783642680717","provider":"Atlantic Books","version":"1.0","type":"link"}