{"product_id":"peptidomimetics-in-organic-and-medicinal-chemistry-the-art-of-transforming-peptides-in-drugs-9781119950608","title":"Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs","description":"\u003cp\u003e • Author(s): Antonio Guarna\u003cbr\u003e • Publisher: Wiley\u003cbr\u003e • Publisher Imprint: Wiley\u003cbr\u003e • BISAC: Chemistry - Physical \u0026amp; Theoretical\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eA peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeptidomimetics in Organic and Medicinal Chemistry\u003c\/i\u003e outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Hardcover","offer_id":45203368345751,"sku":"9781119950608","price":10958.0,"currency_code":"INR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9781119950608.webp?v=1769208538","url":"https:\/\/atlanticbooks.com\/products\/peptidomimetics-in-organic-and-medicinal-chemistry-the-art-of-transforming-peptides-in-drugs-9781119950608","provider":"Atlantic Books","version":"1.0","type":"link"}