{"product_id":"pharmacokinetics-of-moxifloxacin-in-goats-effect-of-bifenthrin-9786206774006","title":"Pharmacokinetics of Moxifloxacin in Goats: Effect of Bifenthrin","description":"\u003cp\u003e • Author(s): Gurmeet Singh | Mudasir Sultana | Adil Mehraj Khan\u003cbr\u003e • Publisher: Scholars' Press\u003cbr\u003e • Publisher Imprint: Scholars' Press\u003cbr\u003e • BISAC: Pharmacology\u003c\/p\u003e\u003cp\u003ePharmacokinetics of moxifloxacin @ 5mg.kg-1.b.wt was studied in healthy and bifenthrin intoxicated goats (n=4), following its IV administration. The MIC of moxifloxacin in plasma was maintained up to 8h in healthy goats whereas it was maintained only up to 6h in bifenthrin-intoxicated goats. The AUC was significantly decreased from 7.86 0.06g.ml-1h to 6.90 0.076g.ml-1h in bifenthrin-intoxicated goats. The distribution half-life (t1\/2) and volume of distribution at steady state Vd(ss) ¬observed were 0.08 0.0008 h and 2.43 0.01L.kg-1 respectively in healthy goats and 0.081 0.0006h and 2.32 0.03L.kg-1 in bifenthrin intoxicated goats. Total body clearance was increased from 636.06 4.68 ml.kg-1h-1 in healthy to 725.4 7.92 ml.kg-1h-1 in intoxicated goats. However, decrease in elimination half life (t1\/2) from 2.81 0.04h to 2.61 0.01h was observed in intoxicated goats. The dosage regimen of moxifloxacin calculated in healthy animals is 4.99 mg.kg-1 followed by 4.73 mg.kg-1 at 12h interval effective against bacterial isolates with MIC\u003c\/p\u003e","brand":"Atlantic Books","offers":[{"title":"Paperback","offer_id":46393928548503,"sku":"9786206774006","price":4770.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9786206774006.webp?v=1769027012","url":"https:\/\/atlanticbooks.com\/products\/pharmacokinetics-of-moxifloxacin-in-goats-effect-of-bifenthrin-9786206774006","provider":"Atlantic Books","version":"1.0","type":"link"}