{"product_id":"progress-in-toxicology-special-topics-volume-2-9783642662935","title":"Progress in Toxicology: Special Topics Volume 2","description":"\u003cp\u003e • Author(s): Gerhard Zbinden\u003cbr\u003e • Publisher: Springer\u003cbr\u003e • Publisher Imprint: Springer\u003cbr\u003e • BISAC: Chemistry - General\u003c\/p\u003e\u003cp\u003eTHE STATE OF THE ART The recent seventies have not been good times for toxicologists. Public confidence in us is shaken, mostly as a consequence of an unhappy sequence of spectacular failures: we have been surprised by a tragic transplacental carcinogenic effect of diethylstilbestrol, an old and widely prescribed synthetic estrogen. We are confronted with a small epidemic of an unusual liver tumor, angiosarcoma, induced by a simple chemical, vinylchloride, whose insiduous toxic potential we failed to \"recognize for years. Our clinical colleagues had to tell us about the ulcerogenic effect of as simple a substance as potassium chloride. We also just learned of an unusual toxic reaction, pseudolupus, developing in people taking a popular fixed-combination drug, venocuran Admit- tedly, we could not have predicted this syndrome, even if we had con- sidered the possibility. We are still unable (to continue this self-flagellation) to explain the relationship between the appetite suppressant arninorex and the sud- denly increased occurrence of a lung disease posing as primary pulmonary hypertension. And worse yet, we have no way to evaluate a new deriva- tive of this class, and to predict whether or not it, too, will produce the deadly condition. We still, to my knowledge, have no plausible ex- planation why and how thalidomide caused phocomelia. Of course, we do diligently a set of teratological experiments with each new drug; we follow a protocol which has the blessing of all governmental regulatory agencies.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Paperback","offer_id":47780777754775,"sku":"9783642662935","price":5967.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9783642662935.webp?v=1778048207","url":"https:\/\/atlanticbooks.com\/products\/progress-in-toxicology-special-topics-volume-2-9783642662935","provider":"Atlantic Books","version":"1.0","type":"link"}