{"product_id":"protein-surface-recognition-approaches-for-drug-discovery-9780470059050","title":"Protein Surface Recognition: Approaches for Drug Discovery","description":"\u003cp\u003e • Author(s): Ernest Giralt\u003cbr\u003e • Publisher: Wiley\u003cbr\u003e • Publisher Imprint: Wiley\u003cbr\u003e • BISAC: Pharmacy\u003c\/p\u003e\u003cp\u003eA new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein\/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e presents a detailed treatment of this strategy, with topics including:\u003c\/p\u003e  *an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective *the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces *examples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems *a survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to \u003ci\u003ein silico\u003c\/i\u003e and \u003ci\u003ein vitro\u003c\/i\u003e methods for the discovery of novel protein ligands.  \u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Hardcover","offer_id":45202313445527,"sku":"9780470059050","price":10155.0,"currency_code":"INR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9780470059050.webp?v=1767668134","url":"https:\/\/atlanticbooks.com\/products\/protein-surface-recognition-approaches-for-drug-discovery-9780470059050","provider":"Atlantic Books","version":"1.0","type":"link"}