{"product_id":"the-genome-in-clinical-medicine-a-comprehensive-two-volume-reference-in-genomic-medicine-9798198536241","title":"The Genome in Clinical Medicine: A Comprehensive Two-Volume Reference in Genomic Medicine","description":"\u003cp\u003e • Author(s): Callum E. Reeve | Maren O. Veldthaus\u003cbr\u003e • Publisher: Independently Published\u003cbr\u003e • Publisher Imprint: Independently Published\u003cbr\u003e • BISAC: Life Sciences - Genetics \u0026amp; Genomics\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe Genome in Clinical Medicine, Volume 1\u003c\/b\u003e \u003ci\u003eHuman Genomic Variation, Epigenetics, and the Molecular Basis of Disease\u003c\/i\u003e\u003c\/p\u003e\u003cp\u003eFor clinicians, residents, and genetic counselors who need genomic medicine at the point of care - not theory, but clinically referenced, guideline-aligned, and immediately applicable. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cb\u003eThe Genome in Clinical Medicine, Volume 1\u003c\/b\u003e is a structured 16-chapter clinical reference covering the full arc of human genomic medicine across 6 parts - from genomic architecture and variant classification to CRISPR gene editing, pharmacogenomics, and prenatal genomics.\u003cp\u003e\u003cb\u003eWhat This Volume Covers\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eGenomic architecture, variant classification, and NGS sequencing platforms\u003c\/li\u003e\n\u003cli\u003eACMG\/AMP variant interpretation - aligned to ClinGen updates and gnomAD v4\u003c\/li\u003e\n\u003cli\u003eEpigenetic mechanisms and disease - DNA methylation, histone modification, chromatin remodelling, non-coding RNA, and imprinting disorders\u003c\/li\u003e\n\u003cli\u003eMendelian inheritance, polygenic risk scores, cancer genomics, and hereditary cancer syndromes\u003c\/li\u003e\n\u003cli\u003ePharmacogenomics and CYP450 implementation - with 2024 CPIC CYP2D6\/CYP2C19 updates\u003c\/li\u003e\n\u003cli\u003eEpigenetic therapeutics - DNMT, HDAC, and EZH2 inhibitors\u003c\/li\u003e\n\u003cli\u003eCRISPR-Cas9 and ex vivo HSC gene editing, including Casgevy (2023)\u003c\/li\u003e\n\u003cli\u003eClinical genomic testing pathways, EHR-integrated genomic decision support, and NIPT\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003eBuilt for Clinical Use\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e20 original high-quality clinical figures including ACMG\/AMP interpretation workflow, PRS risk stratification, two-hit tumour suppressor model, CRISPR-Cas9 DSB repair pathways, and prenatal decision pathway\u003c\/li\u003e\n\u003cli\u003eReferenced to current international guidelines: ACMG\/AMP, CPIC, ClinGen, ACMG SF v3.2, 2025 ACMG prenatal guidelines, and FDA-approved gene therapies\u003c\/li\u003e\n\u003cli\u003eFull subject index (90+ entries), abbreviations glossary (70 entries), and complete reference lists per chapter - AMA 11th edition\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003eWho This Book Is For\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eClinicians and hospitalists integrating genomics into practice - Internal medicine residents and fellows - Genetic counselors - Advanced medical students - Specialists in oncology, cardiology, neurology, and reproductive medicine\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eVolume 2 - The Microbial Genome: Dysbiosis, the Gut, and Clinical Practice - in preparation.\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThis is a precise, no-filler clinical reference built for the era of genomic medicine. Every chapter moves from molecular mechanism to clinical application - structured for rapid use on the ward, in clinic, and in consultation.\u003c\/p\u003e\u003cbr\u003e","brand":"Independently Published","offers":[{"title":"Paperback","offer_id":47890482888855,"sku":"9798198536241","price":19807.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9798198536241.webp?v=1781180199","url":"https:\/\/atlanticbooks.com\/products\/the-genome-in-clinical-medicine-a-comprehensive-two-volume-reference-in-genomic-medicine-9798198536241","provider":"Atlantic Books","version":"1.0","type":"link"}