{"product_id":"the-theory-of-response-adaptive-randomization-in-clinical-trials-9780471653967","title":"The Theory of Response-Adaptive Randomization in Clinical Trials","description":"\u003cp\u003e • Author(s): Feifang Hu\u003cbr\u003e • Publisher: Wiley-Interscience\u003cbr\u003e • Publisher Imprint: Wiley-Interscience\u003cbr\u003e • BISAC: Probability \u0026amp; Statistics - General\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePresents a firm mathematical basis for the use of response-adaptive randomization procedures in practice\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eThe Theory of Response-Adaptive Randomization in Clinical Trials\u003c\/i\u003e is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.\u003c\/p\u003e \u003cp\u003eThis timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:\u003c\/p\u003e  *How does response-adaptive randomization affect power? *Can standard inferential tests be applied following response-adaptive randomization? *What is the effect of delayed response? *Which procedure is most appropriate and how can \"most appropriate\" be quantified? *How can heterogeneity of the patient population be incorporated? *Can response-adaptive randomization be performed with more than two treatments or with continuous responses?  \u003cp\u003eThe answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:\u003c\/p\u003e  *The relationship between power and response-adaptive randomization *The general result for determining asymptotically best procedures *Procedures based on urn models *Procedures based on sequential estimation *Implications for the practice of clinical trials  \u003cp\u003eUseful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.\u003c\/p\u003e","brand":"Wiley-Interscience","offers":[{"title":"Hardcover","offer_id":45201819173015,"sku":"9780471653967","price":14429.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/3471\/1191\/files\/9780471653967.webp?v=1767307640","url":"https:\/\/atlanticbooks.com\/products\/the-theory-of-response-adaptive-randomization-in-clinical-trials-9780471653967","provider":"Atlantic Books","version":"1.0","type":"link"}