Reducing, Refining And Replace The Use of Animal In Toxcity Testing (Hardbound - 2013)

About the Book
Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. Many methods currently involve laboratory animals. Alternative procedures are now being developed which reduce, refine, or replace animal usage. Aimed at postgraduates, academics and industrialists, this book describes the ever-expanding "toolbox" of methods now available. These often result from our growing understanding of the biochemical pathways that mediate toxicity. By combining various techniques to build a "weight of evidence", toxicologists are developing mechanistically based alternatives to experimentation on live animals. This text also emphasizes the importance of adequate test validation, reliability and relevance.