• ISBN13: 9780824702946
• Binding: Hardcover
• Subject: Medical, Nursing and Health Sciences
• Publisher: T&F
• Publisher Imprint: Mar Dekker
• Publication Date: April 6, 2001
• Pages: 406
• Original Price: GBP 180.0
• Language: English
• Edition: N/A
• Item Weight: 613 grams

About the Book Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation <p/>This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. <p/>Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines <p/>Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment<br><li>reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis <br></li><li>calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens <br></li><li>reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models <br></li><li>discusses the threshold concept of carcinogenesis <br></li><li>demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens <br></li><li>considers structural activity relationship (SAR) analysis of chemical carcinogenicity <br></li><li>describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays <br></li><li>illustrates the use of genetic biomarkers for dosimetry analysis <br></li><li>and more <br>Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.</li>