Name: Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease
Brand: Springer Verlag
SKU: 9780387097886
Price: 6181.0 INR
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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

by Alexander Sigalov

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ISBN13: 9780387097886
Binding: Hardcover
Subject: Bio-Science and Agriculture
Publisher: Springer Verlag
Publisher Imprint: Springer V
Publication Date: January 1, 2009
Pages: 357
Original Price: EUR 229.0
Language: English
Edition: N/A
Item Weight: 794 grams
BISAC Subject(s): Life Sciences / Biology and Life Sciences / Anatomy & Physiology

About The Book

Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. This text describes the molecular basis of MIRR-mediated transmembrane signaling.

About The Author

ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity in the context of transmembrane signal transduction, the molecular mechanisms underlying immune receptor-mediated signaling and ways to control these processes and thus to modulate the immune response, as well as the development and applications of novel targets and strategies for innovative immune therapy. He discovered and investigated a very unusual and unique biophysical phenomenon, the homooligomerization of intrinsically disordered proteins, thus providing the first evidence for the existence of specific interactions between unfolded protein molecules. In the field of immunology, he unraveled a long-standing mystery of transmembrane signaling and immune cell activation triggered by multichain immune recognition receptors. Later, he developed a novel concept of platelet inhibition and invented a novel class of platelet inhibitors. In the field of immune therapy, he proposed new therapeutic strategies for a variety of malignancies and immune disorders, including immunodeficiencies, inflammatory and autoimmune diseases, allergy and HIV. He is a member of the American Association for the Advancement of Science and the Biophysical Society, USA. Alexander Sigalov received his academic degrees (MSc in Chemistry and a PhD in Organic Chemistry) from Moscow State University, Russia.

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