Proteassoma: marcador tumoral numa população marroquina

Name: Proteassoma: marcador tumoral numa população marroquina
Brand: Edicoes Nosso Conhecimento
SKU: 9786209854576
Price: 6921.0 INR
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by Hassan Filali

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ISBN13: 9786209854576
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: March 25, 2026
Pages: 112
Original Price: USD 77.0
Language: Portuguese
Edition: N/A
Item Weight: 159 grams
BISAC Subject(s): General

About The Book

Contexto: A degrada��o regulada das prote�nas intracelulares desempenha um papel essencial na maioria dos processos biol�gicos, nomeadamente no controlo da prolifera��o e da diferencia��o celular. Nos eucariotas, a prote�lise intracelular � assegurada em grande parte pelo sistema ubiquitina/proteassoma. In�meras disfun��es do mecanismo de degrada��o t�m sido associadas a patologias humanas, nomeadamente neoplasias hematol�gicas. Objetivos: o objetivo do nosso estudo � detetar uma eventual rela��o entre o aparecimento de certos tipos de cancro do sangue e o processo de envelhecimento, atrav�s da evolu��o do proteassoma. Metodologia: a an�lise quantitativa e funcional do proteassoma foi realizada a n�vel subcelular e s�rico durante um fen�meno fisiol�gico (o envelhecimento) e patol�gico (hemopatia maligna), atrav�s da t�cnica de ELISA em sandu�che e do acompanhamento da fluoresc�ncia emitida ap�s a digest�o enzim�tica de pept�deos fluorog�nicos espec�ficos da atividade quimotripsina-like. A t�cnica de CMF permitiu demonstrar o processo de migra��o transmembranar das subunidades prosomais provenientes.

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