Terapia komórkami macierzystymi: nowa metoda leczenia chorób klębuszków nerkowych
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W organizmie czlowieka nerka jest wyjątkowym narządem, kt�ry charakteryzuje się wysokim stopniem r�żnicowania końcowego i ma bardzo ograniczoną zdolnośc do regeneracji po urazie lub uszkodzeniu. Dlatego też po wystąpieniu chor�b klębuszk�w nerkowych dochodzi zazwyczaj do schylkowej niewydolności nerek (ESRD), wymagającej dializoterapii lub przeszczepu nerki (RT) w celu poprawy jakości życia. Jednak ze względu na niedob�r nerek do przeszczepu oraz powiklania związane z przeszczepem, takie jak odrzucenie przeszczepu, zachorowalnośc i śmiertelnośc związane z immunosupresją, w tym oslabienie odporności, zaburzenia metaboliczne, infekcje i nowotwory zlośliwe, RT pozostaje wyzwaniem. Dostępne opcje terapeutyczne w leczeniu chor�b klębuszk�w nerkowych obejmują strategie leczenia objawowego mające na celu op�źnienie progresji do ESRD. Terapia oparta na kom�rkach macierzystych (SCT) stanowi nową, innowacyjną metodę leczenia takich chor�b ze względu na jej zdolnośc do hamowania stanu zapalnego, odbudowy umierających tkanek/kom�rek oraz wspomagania regeneracji. Niniejszy przegląd skupia się na SCT w leczeniu chor�b klębuszk�w nerkowych, w tym na r�żnych wykorzystywanych źr�dlach kom�rek oraz najnowszych osiągnięciach w badaniach przedklinicznych i klinicznych.
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