Tolerância no transplante renal alogénico de dador vivo

Name: Tolerância no transplante renal alogénico de dador vivo
Brand: Edicoes Nosso Conhecimento
SKU: 9786209822629
Price: 7008.0 INR
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by Aruna V. Vanikar

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ISBN13: 9786209822629
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: April 29, 2026
Pages: 108
Original Price: USD 78.0
Language: Portuguese
Edition: N/A
Item Weight: 155 grams
BISAC Subject(s): General

About The Book

A toler�ncia no transplante pode ser definida como a sobreviv�ncia normal do enxerto sem imunossupress�o, mantendo a imunidade intacta. As estrat�gias de indu��o de toler�ncia (TI) incluem a indu��o de quimerismo e/ou a dele��o clonal. A transfus�o espec�fica do dador (DST) e as c�lulas estaminais (SCs) t�m surgido como estrat�gias de TI. Neste estudo aberto, paralelo, de dois bra�os, sob condicionamento n�o mieloablativo, com DST como primeiro bra�o e SCs como segundo bra�o, sem utiliza��o de imunossupress�o convencional. A monitoriza��o incluiu SCr (mg/dL), DSA e MLR. Foram planeadas bi�psias de protocolo ap�s 100 dias e anualmente nos doentes que assim o desejassem. Em caso de rejei��o/DSA/MLR, foi planeada imunosupress�o de resgate. A sobreviv�ncia dos doentes nos primeiros 2 anos foi de 100% em ambos os bra�os; aos 5 anos ap�s o transplante, 80% com SC e 90% com DST. A sobreviv�ncia do enxerto censurada por morte no primeiro ano foi de 100% em ambos os grupos e, aos 5 anos, de 80% com SC e 70% com DST. A m�dia de SCr foi de 1,52 com SC e de 1,97 com DST. Cinco doentes do grupo SC e 3 do grupo DST tiveram TI bem-sucedida. A MLR foi negativa em ambos os grupos. A DSA surgiu em 2 doentes do grupo SC sem disfun��o do enxerto e em 4 do grupo DST, causando disfun��o do enxerto. Assim, as SCs facilitam a TI na LDRT sob condicionamento n�o mieloablativo.

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