Tolleranza nel trapianto renale allogenico da donatore vivente

Name: Tolleranza nel trapianto renale allogenico da donatore vivente
Brand: Edizioni Sapienza
SKU: 9786209898099
Price: 7010.0 INR
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by Aruna V. Vanikar

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ISBN13: 9786209898099
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: April 29, 2026
Pages: 112
Original Price: USD 78.0
Language: Italian
Edition: N/A
Item Weight: 159 grams
BISAC Subject(s): General

About The Book

La tolleranza al trapianto pu� essere definita come la sopravvivenza normale dell'innesto in assenza di immunosoppressione, con il mantenimento intatto del sistema immunitario. Le strategie di induzione della tolleranza (TI) comprendono l'induzione del chimerismo e/o la delezione clonale. La trasfusione specifica del donatore (DST) e le cellule staminali (SC) sono emerse come strategie di TI. In questo studio parallelo a due bracci in aperto, con condizionamento non mieloablativo, il primo braccio prevedeva la DST e il secondo le SC, senza l'uso di immunosoppressione convenzionale. Il monitoraggio includeva SCr (mg/dL), DSA e MLR. Le biopsie previste dal protocollo erano pianificate dopo 100 giorni e annualmente nei pazienti consenzienti. In caso di rigetto/DSA/MLR, era prevista un'immunosoppressione di salvataggio. La sopravvivenza dei pazienti nei primi 2 anni � stata del 100% in entrambi i bracci; a 5 anni dal trapianto dell'80% con le SC e del 90% con la DST. La sopravvivenza del trapianto censurata per morte nel primo anno � stata del 100% in entrambi i bracci e, a 5 anni, dell'80% con SC e del 70% con DST. La SCr media era di 1,52 con SC e di 1,97 con DST. Cinque pazienti del braccio SC e 3 del braccio DST hanno avuto una TI riuscita. La MLR era negativa in entrambi i gruppi. La DSA � comparsa in 2 pazienti del gruppo SC senza disfunzione dell'innesto e in 4 del gruppo DST causando disfunzione dell'innesto.

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