• ISBN13: 9780854048465
• Binding: Hardcover
• Subject: Chemistry
• Publisher: Royal Society of Che
• Publisher Imprint: RSC
• Publication Date: January 1, 2008
• Pages: 200
• Original Price: GBP 73.99
• Language: English
• Edition: N/A
• Item Weight: 431 grams
• BISAC Subject(s): Pharmacology, Chemistry / Clinical, and Gastroenterology

From the Back Cover
Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. In recent years there have been tremendous advances in the understanding of the mechanisms behind the toxicity and bioactivity of different Bile acids and these are covered at length in this book. Prior to the publication of this book there was no single source of information on the toxicology and bioactivity properties of Bile acids and the book uniquely collects all the relevant information together regarding the role of Bile acids in human disease. Additionally, as Bile acids are synthesised from cholesterol, there is wide recognition of the role for Bile acids in obesity linked diseases and this is also covered in this new publication. The book is edited by two experts in the field who have been involved in Bile acid research for several years and who are closely involved with major research groups in the UK, Europe and the US actively engaged in Bile acid research. The book also includes contributions by experts in the field and this book will appeal to all researchers who wish to understand the basic toxicology and bioactivity of Bile acids.

Gareth Jenkins, Institute of Life Science, Swansea School of Medicine has been a Genetic Toxicologist for the past 12 years and has been interested in the toxicology of Bile acids and their role in GI Tract cancer for the past 6 years. Bile acid induced toxicity and geno-toxicity are currently a focus of his research group and his specific research interests are in GI tract cancers (oesophageal, gastric, colorectal) and in particular the early stages of cancer development and the role of Bile acids in these cancers, particularly oesophageal cancer. Laura Hardie is currently Oesophageal Research Group Leader, at the University of Leeds. Her previous posts include Study Director, National Institute for Biological Standards and Control, London and Senior Scientist for Obesity Research, Rowett Research Institute, Aberdeen. Her current research group in Leeds is focussed on understanding the key molecular mechanisms associated with the development of oesophageal cancer and on understanding how bile acids present in heartburn, promote the disease process. Also, with her background in obesity research, she has a keen interest in understanding the interaction between obesity, bile acids and certain types of cancer.