Breaking the Fibrin Code: The Fibrinolysis Fix for Microclots & Arthritis
Systemic Enzyme Therapy-Serrapeptase, Nattokinase & Lumbrokinase-to Lower Fibrinogen, Relieve Joint Pain & Calm Chronic Inflammation (TOBIN Framework - Lab Testing - Dosing Protocols)
If you've tried anti-inflammatories, joint supplements, and even physical therapy yet still wake up stiff and swollen, you may be fighting the wrong enemy. The hidden culprit behind persistent arthritis pain, microclots, and "mystery" inflammation is often excess fibrin and fibrinogen-the sticky protein mesh that thickens blood, chokes microcirculation, ignites immune signaling, and locks pain into your joints.
This breakthrough, clinician-written guide by Benoit Tano, MD, PhD reveals the complete, evidence-based roadmap to identify, monitor, and dissolve problem fibrin using systemic enzyme therapy-with clear protocols for nattokinase, serrapeptase, and lumbrokinase, plus bromelain, papain, trypsin/chymotrypsin, and smart cofactors (rutin, quercetin, K2, magnesium, vitamin C, omega-3).
What you'll learn inside
Fibrin & Arthritis, finally explained: how fibrin/fibrinogen drive joint stiffness, swelling, and pain-plus their roles in microclots, long-term inflammation, fatigue, brain fog, and cardiovascular risk.
The TOBIN Framework: how Toxin overload, Hormonal imbalance, Infections, and Nutrient deficiencies accelerate fibrin formation-and how to reverse each input.
Systemic Enzyme Science, decoded: exact pathways (plasmin activation, direct fibrin hydrolysis, FXIIIa crosslinking impacts, PAI-1 dynamics) explained in plain language.
Clinically usable dosing protocols: tiered plans for beginners, sensitive patients, and advanced cases-including loading vs. maintenance, empty-stomach timing, cycling strategies, and stacking rules for SPU/FU/GDU/PU activity units.
Lab testing that actually helps: how to order, interpret, and track Fibrinogen (Clauss), D-dimer, TEG/ROTEM, PAI-1, vWF, CRP/ESR, and when to repeat labs to confirm progress.
Safety first: anticoagulant/antiplatelet cautions, peri-operative pause rules, and how to mitigate Herx-type reactions or GI sensitivity.
A superior blueprint formula: the book's reference design for a next-generation multi-enzyme, multi-pathway supplement that targets fibrin from every angle-paired with nutrient cofactors to support microcirculation and vascular integrity.
Food & lifestyle plan for fibrin balance: anti-inflammatory meals, natto and pineapple strategies, hydration/electrolytes, breathwork, heat/sauna, movement, and sleep protocols that enhance natural fibrinolysis.
Case snapshots & quick wins: how readers used enzyme-guided protocols to reduce morning stiffness, improve range of motion, and support healthy lab trends.
Who this book is for
Anyone with arthritic pain, joint stiffness, swelling, tendon issues, or unexplained inflammation.
People exploring microclot/microcirculation support or post-illness recovery.
Health professionals (integrative, functional, rheumatology, cardiometabolic, pain, sports) who want actionable, lab-directed protocols.
If you're ready to move beyond symptom management and address the root biochemistry of stubborn pain and inflammation, Breaking the Fibrin Code gives you the map, the metrics, and the methods.
