Cytokines Pro-Inflammatoires Et Anti-Inflammatoires
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Les maladies parodontales sont des maladies inflammatoires dans lesquelles les facteurs �tiologiques microbiens induisent une s�rie de r�ponses de l'h�te qui m�diatisent les �v�nements inflammatoires. L'inflammation physiologique est un r�seau bien orchestr� de cellules, de m�diateurs et de tissus. Les cytokines sont des prot�ines de signalisation qui aident � contr�ler l'inflammation dans l'organisme. Les cytokines jouent un r�le important dans la r�paration des l�sions tissulaires induites chimiquement, dans le d�veloppement et la progression du cancer, dans le contr�le de la r�plication cellulaire et de l'apoptose, et dans la modulation des r�actions immunitaires telles que la sensibilisation. Les cytokines sont des r�gulateurs majeurs de l'immunit� inn�e et adaptative qui permettent aux cellules du syst�me immunitaire de communiquer sur de courtes distances. La th�rapie par cytokines visant � activer le syst�me immunitaire des patients atteints de cancer a �t� une modalit� de traitement importante et continue d'�tre un �l�ment cl� de la recherche clinique actuelle sur le cancer. Une meilleure compr�hension de la fa�on dont les cytokines modulent la croissance et la diff�renciation cellulaires, la migration et l'activation des cellules en r�ponse � des produits chimiques et dans des �tats physiologiques normaux et alt�r�s promet d'apporter d'�normes avantages � la m�decine et � la biologie buccale.
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