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Évaluation de l'estriol by Aakifa Ahmad, Naushad Alam

Évaluation de l'estriol

by Aakifa Ahmad , Naushad Alam
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Book cover type: Paperback
  • ISBN13: 9786209590498
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 84
  • Original Price: GBP 38.19
  • Language: French
  • Edition: N/A
  • Item Weight: 123 grams
  • BISAC Subject(s): Pharmacology

L'effet de l'estriol, le troisi�me oestrog�ne, a �t� �valu� pour son effet sur le mod�le d'�pileptogen�se pentyl�net�trazole (PTZ) chez la souris, suivi d'une �valuation des changements induits par l'allumage dans les fonctions cognitives et motrices. L'allumage a �t� induit par un traitement tous les 2 jours avec du PTZ (25 mg/kg, i.p.) pendant 5 semaines. La gravit� des crises lors de l'induction de l'allumage et le pourcentage d'incidence d'animaux allum�s au bout de 5 semaines ont �t� enregistr�s. La fonction motrice a �t� �valu�e � l'aide d'un appareil de mesure de la force de pr�hension tandis que la m�moire spatiale a �t� �valu�e dans un labyrinthe crois�. L'estriol (0,005 et 0,01 mg/kg i.p.) a r�duit le temps d'induction de l'allumage de 5 semaines � 3 et 2 semaines respectivement pour les souris m�les et femelles et a augment� le pourcentage d'incidence des convulsions. Le clomif�ne (0,9 mg/kg i.p.) a retard� le d�veloppement du petit bois et produit des effets anticonvulsivants. Il a �galement partiellement invers� les effets proconvulsivants de l'estriol. Lors du test de force de pr�hension et du comportement d'alternance spontan�e, une diminution significative a �t� observ�e chez les souris allum�es, qui a encore �t� r�duite par un pr�traitement � l'estriol.

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