Eziologia complessa della nefropatia endemica e possibili misure profilattiche
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� stata studiata l'incidenza della nefropatia micotossica negli animali da allevamento e nell'uomo. Sono stati analizzati i fattori eziologici che contribuiscono allo sviluppo della malattia. � stata studiata l'importanza dell'interazione congiunta delle micotossine e delle micotossine mascherate nella complessa eziologia della nefropatia micotossica. � stata analizzata l'importanza dei bassi livelli di contaminazione delle combinazioni target di micotossine spesso somministrate a suini/pulcini/esseri umani nella pratica. � stata effettuata una stima dell'esposizione umana alle micotossine nefrotossiche nelle aree endemiche. Sono stati descritti il metabolismo, la farmacocinetica, i meccanismi d'azione e l'eliminazione della micotossina nefrotossica ocratossina A. Sono stati descritti anche i principali cambiamenti biochimici e patomorfologici ai fini di una diagnosi tempestiva. Sono state studiate le somiglianze morfologiche, funzionali e tossicologiche tra la nefropatia umana e quella animale. � stato studiato il possibile pericolo dei bassi livelli di contaminazione delle combinazioni target di micotossine spesso somministrate a suini/polli/esseri umani nella pratica e � stata effettuata una valutazione del rischio. Sono stati suggeriti alcuni modi efficaci di profilassi. � stato suggerito il modo pi� efficace di controllo dell'igiene nei macelli in vista del pericolo per la salute umana.
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