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Formulation Et Évaluation de la Nanosuspension d'Itraconazole by Kavita Attri, Avneet Kaur

Formulation Et Évaluation de la Nanosuspension d'Itraconazole

by Kavita Attri , Avneet Kaur
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Book cover type: Paperback
  • ISBN13: 9786209413223
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 108
  • Original Price: GBP 52.98
  • Language: French
  • Edition: N/A
  • Item Weight: 155 grams
  • BISAC Subject(s): General

La faible solubilit� dans l'eau des ingr�dients pharmaceutiques actifs (IPA) repr�sente un d�fi important dans l'administration orale des m�dicaments, entra�nant une biodisponibilit� r�duite et une efficacit� th�rapeutique compromise. Cette �tude visait � r�soudre ce probl�me en d�veloppant une nanosuspension optimis�e d'itraconazole pour l'administration intranasale, am�liorant potentiellement la disponibilit� du m�dicament � travers la barri�re h�mato-enc�phalique.Une nanosuspension a �t� pr�par�e et caract�ris�e � l'aide de diverses techniques analytiques. Les analyses FTIR et DSC ont permis de v�rifier la structure chimique et l'�tat cristallin du m�dicament . Un plan de Box-Behnken a �t� utilis� pouroptimiser la formulation, ce qui a permis d'obtenir des nanoparticules de taille, d'indice de polydispersit�, de potentiel z�ta et d'efficacit� de pi�geage favorables. L'imagerie TEM a r�v�l� une structure coeur-coquille des nanoparticules. La nanosuspension optimis�e a d�montr� une meilleure lib�ration du m�dicament par rapport � une suspension conventionnelle. Ces r�sultats sugg�rent que la nanosuspension d'itraconazole d�velopp�e a le potentiel de am�liorer la solubilit� et la biodisponibilit� du m�dicament.

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