Formulation et optimisation des timbres transdermiques

Name: Formulation et optimisation des timbres transdermiques
Brand: Editions Notre Savoir
SKU: 9786630087963
Price: 8358.0 INR
Availability: InStock

by Mukesh Rani , Seema Rohilla

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ISBN13: 9786630087963
Binding: Paperback
Subject: N/A
Publisher: Editions Notre Savoir
Publisher Imprint: Editions Notre Savoir
Publication Date: May 27, 2026
Pages: 132
Original Price: GBP 66.0
Language: French
Edition: N/A
Item Weight: 186 grams
BISAC Subject(s): Pharmacology

About The Book

Le lisinopril est un agent antihypertenseur indiqu� pour la pr�vention de l'hypertension, de l'infarctus aigu du myocarde et de la n�phropathie diab�tique. Il s'agit d'un inhibiteur de l'enzyme de conversion de l'angiotensine (ECA). Il a une demi-vie courte et subit un m�tabolisme de premier passage variable. Il doit �tre administr� deux ou trois fois par jour, ce qui entra�ne une mauvaise observance de la part du patient. Dans ce travail, on a tent� de formuler et d'�valuer le TDDS pour la lib�ration prolong�e du lisinopril par la m�thode d'�vaporation du solvant. Le faible poids mol�culaire, la bonne perm�abilit� et la demi-vie plus courte du m�dicament en ont fait un candidat appropri� pour le d�veloppement de patchs transdermiques. L'objectif principal de la formulation du syst�me transdermique �tait de prolonger la dur�e de lib�ration du m�dicament, de r�duire la fr�quence d'administration et d'am�liorer l'observance du patient. La caract�risation de la compatibilit� a �t� effectu�e par la m�thode IR. En utilisant un plan factoriel de 32, neuf formulations ont �t� pr�par�es en utilisant des polym�res hydrophiles (HPMC) et hydrophobes (�thylcellulose) avec des plastifiants et des am�liorateurs de perm�ation s�lectionn�s. La membrane de support PVA a �t� utilis�e comme substrat pour verser la solution polym�re. Les patchs pr�par�s ont �t� �valu�s pour l'apparence physique, l'�paisseur.

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