Formulazione e ottimizzazione dei cerotti transdermici

Name: Formulazione e ottimizzazione dei cerotti transdermici
Brand: Edizioni Sapienza
SKU: 9786630090529
Price: 7347.0 INR
Availability: InStock

by Mukesh Rani , Seema Rohilla

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ISBN13: 9786630090529
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: May 24, 2026
Pages: 128
Original Price: GBP 58.0
Language: Italian
Edition: N/A
Item Weight: 182 grams
BISAC Subject(s): Pharmacology

About The Book

Il lisinopril � un agente antipertensivo indicato per la prevenzione dell'ipertensione, dell'infarto acutemiocardico e della nefropatia diabetica. � un inibitore dell'enzima di conversione dell'angiotensina (ACE). Ha un'emivita breve e subisce un metabolismo di primo passaggio variabile. � necessario somministrarlo due o tre volte al giorno, con conseguente scarsa compliance del paziente. In questo lavoro si � cercato di formulare e valutare i TDDS per il rilascio prolungato di lisinopril con il metodo dell'evaporazione dei solventi. Il basso peso molecolare, la buona permeabilit� e l'emivita pi� breve del farmaco lo hanno reso un candidato adatto per lo sviluppo di un patch transdermico. L'obiettivo principale della formulazione del sistema transdermico era quello di prolungare il tempo di rilascio del farmaco, ridurre la frequenza di somministrazione e migliorare la compliance del paziente. La caratterizzazione della compatibilit� � stata effettuata con il metodo IR. Utilizzando un disegno a 32 fattori sono state preparate nove formulazioni utilizzando polimeri idrofili (HPMC) e idrofobici (etilcellulosa) insieme a plastificanti e stimolatori della permeazione selezionati. La membrana di supporto in PVA � stata utilizzata come substrato per versare la soluzione polimerica. I cerotti preparati sono stati valutati per aspetto fisico, spessore.

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