Formulierung und Optimierung von transdermalen Pflastern

Name: Formulierung und Optimierung von transdermalen Pflastern
Brand: Verlag Unser Wissen
SKU: 9786630082845
Price: 8358.0 INR
Availability: InStock

by Mukesh Rani , Seema Rohilla

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ISBN13: 9786630082845
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: May 24, 2026
Pages: 132
Original Price: GBP 66.0
Language: German
Edition: N/A
Item Weight: 186 grams
BISAC Subject(s): Pharmacology

About The Book

Lisinopril ist ein blutdrucksenkendes Mittel, das zur Vorbeugung von Bluthochdruck, akutem Herzinfarkt und diabetischer Nephropathie eingesetzt wird. Es ist ein Angiotensin-Converting-Enzyme(ACE)-Hemmer. Es hat eine kurze Halbwertszeit und unterliegt einem variablen First-Pass-Metabolismus. Es muss zwei- oder dreimal t�glich verabreicht werden, was zu einer schlechten Patientencompliance f�hrt. In dieser Arbeit wurde ein Versuch unternommen, TDDS f�r die verz�gerte Freisetzung von Lisinopril durch L�sungsmittelverdampfung zu formulieren und zu bewerten. Das niedrige Molekulargewicht, die gute Permeabilit�t und die k�rzere Halbwertszeit des Medikaments machten es zu einem geeigneten Kandidaten f�r die Entwicklung eines transdermalen Pflasters. Das Hauptziel der Formulierung des transdermalen Systems war es, die Freisetzungszeit des Medikaments zu verl�ngern, die H�ufigkeit der Verabreichung zu verringern und die Patientencompliance zu verbessern. Die Kompatibilit�t wurde mit der IR-Methode charakterisiert. Unter Verwendung eines 32-faktoriellen Designs wurden neun Formulierungen mit hydrophilen (HPMC) und hydrophoben (Ethylcellulose) Polymeren zusammen mit ausgew�hlten Weichmachern und Permeationsverbesserern hergestellt.  Die PVA-Tr�germembran wurde als Substrat f�r das Ausgie en der Polymerl�sung verwendet.  Die hergestellten Pflaster wurden auf ihr physikalisches Aussehen und ihre Dicke hin untersucht.

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