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Granat tunezyjski stymuluje transport glukozy do mięśni by Amine Ben Abdennabi

Granat tunezyjski stymuluje transport glukozy do mięśni

by Amine Ben Abdennabi
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Book cover type: Paperback
  • ISBN13: 9786209539077
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Publication Date:
  • Pages: 52
  • Original Price: GBP 38.19
  • Language: Polish
  • Edition: N/A
  • Item Weight: 82 grams
  • BISAC Subject(s): Pharmacology

Granat, Punica granatum, byl stosowany jako lekarstwo na cukrzycę. Badania wykazaly hipoglikemiczne dzialanie ekstrakt�w z granatu poprzez r�żne mechanizmy. Jednak do tej pory żadne badania nie wykazaly wplywu granatu na transport glukozy do mięśni. Celem tego projektu jest ocena przeciwcukrzycowego dzialania ekstrakt�w z granatu na transport glukozy do kom�rek mięśniowych w zależności od odmiany i stadium dojrzalości owoc�w oraz wyjaśnienie mechanizm�w dzialania. Wyniki wykazaly, że tylko odmiana granatu Gabsi znacząco stymuluje transport glukozy w por�wnaniu z grupą kontrolną, nie wykazując przy tym toksyczności. Efekt ten jest bardziej wyraźny w fazie dojrzalości owoc�w (po 6 miesiącach) niż w fazie kwitnienia. Ponadto ekstrakt z kwiat�w stymuluje niezależną od insuliny ścieżkę AMPK i zwiększa poziom ekspresji specyficznych transporter�w glukozy (GLUT-4). Z drugiej strony ekstrakt z dojrzalych owoc�w, opr�cz tych dw�ch mechanizm�w, silnie aktywuje r�wnież zależną od insuliny ścieżkę AKT. Podsumowując, badanie to przedstawia nowy mechanizm dzialania przeciwcukrzycowego granatu, kt�ry jest zależny od odmiany.

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