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Il targeting temporale dei recettori P2X4 nell'ictus by Reza Mosaddeghi Heris, Hamed Aghazadeh, Amir Tahavvori

Il targeting temporale dei recettori P2X4 nell'ictus

by Reza Mosaddeghi Heris , Hamed Aghazadeh , Amir Tahavvori
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Book cover type: Paperback
  • ISBN13: 9786209368547
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 168
  • Original Price: GBP 65.16
  • Language: Italian
  • Edition: N/A
  • Item Weight: 232 grams
  • BISAC Subject(s): General

Questo libro esplora il potenziale terapeutico emergente della modulazione della segnalazione purinergica nelle diverse fasi del danno cerebrovascolare. Presenta una panoramica completa di come l'attivazione o l'inibizione del recettore P2X4 influenzi la polarizzazione microgliale, la neuroinfiammazione, la sopravvivenza neuronale e gli esiti comportamentali post-ictus. Integrando neuroscienze molecolari, farmacologia e medicina traslazionale, il testo delinea il duplice ruolo temporale dei recettori P2X4: neuroprotezione precoce nell'ischemia acuta e regolazione della neuroplasticit� per mitigare la depressione cronica post-ictus. Il libro mette in evidenza recenti modelli sperimentali, ligandi selettivi per i recettori e prospettive cliniche per la progettazione di interventi sensibili al fattore tempo che colleghino la neuroprotezione acuta al recupero a lungo termine della salute mentale nei pazienti colpiti da ictus.

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