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Ksenotransplantacja by Naseem Begum

Ksenotransplantacja

by Naseem Begum
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Book cover type: Paperback
  • ISBN13: 9786209300141
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 116
  • Original Price: GBP 66.9
  • Language: German
  • Edition: N/A
  • Item Weight: 164 grams
  • BISAC Subject(s): General

Die Xenotransplantation entwickelt sich zu einer potenziellen Behandlungsmethode f�r verschiedene Erkrankungen, bei denen Organ- oder Zelltransplantationen die einzige �berlebenschance f�r die Patienten darstellen. In den meisten F�llen wurden Schweine als Spender in Betracht gezogen, doch der Erfolg wurde durch das Problem der hyperakuten Absto ung aufgrund des Vorhandenseins des α-Gal-Epitops auf Schweinezellen behindert, gegen das im menschlichen K�rper bereits Antik�rper gebildet wurden. Au erdem besteht ein ernsthaftes Risiko der Xenozoonose. Die aktuelle Forschung weltweit konzentriert sich darauf, diesen Problemen entgegenzuwirken. Wir haben versucht, eine andere Strategie zu verfolgen, indem wir nach einer alternativen tierischen Quelle gesucht haben. Wir haben uns auf Ziegen als potenzielle Spenderkandidaten konzentriert. Wir haben gezeigt, dass Ziegenhepatocyten das induzierte Leberversagen bei Wistar-Ratten r�ckg�ngig gemacht haben. Dar�ber hinaus haben wir auch nachgewiesen, dass das α-Gal-Epitop auf Ziegenzellen wahrscheinlich nicht vorhanden ist, und damit einen neuen Ansatz f�r die weitere Forschung in dieser Richtung er�ffnet.

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