Resposta mucosa de coelhos e bovinos às vacinas contra a pasteurelose
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No Sud�o, a septicemia hemorr�gica (HS) � uma doen�a contagiosa, peraguda, aguda ou cr�nica altamente fatal em animais. A doen�a � end�mica na maior parte das regi�es tropicais e subtropicais da �sia e �frica, e � causada pelos ser�tipos B:2 e E:2 da Pasteurella multocida. Ambos os ser�tipos foram relatados e s�o end�micos no meu pa�s. O controlo da doen�a depende principalmente da imuniza��o com vacinas adjuvantes inativadas (bacterina). As estirpes vacinais P. multocida B:2 e E:2 s�o rotineiramente utilizadas para a imuniza��o contra a HS. A investiga��o b�sica que caracteriza este livro consistiu em comparar as efici�ncias da resposta imunit�ria mucosa � vacina��o sist�mica contra a infec��o por Pasteurella multocida em coelhos e bovinos. As vacinas utilizadas neste estudo foram bacterina, lisado celular e tox�ide, misturadas com �leo de amendoim (I: 1 v/v) com adjuvante incompleto de Freund, que foi testado como adjuvante mucoso para administrar as vacinas. De acordo com os resultados, recomenda-se a realiza��o de mais estudos sobre a P. multocida para testar a administra��o das vacinas por via intranasal, em vez de outras vias, principalmente para reduzir a carga infecciosa o suficiente para permitir o sucesso das novas vacinas.
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