Sistemi Di Consegna Dei Farmaci Galleggianti - Una Revisione

Name: Sistemi Di Consegna Dei Farmaci Galleggianti - Una Revisione
Brand: Edizioni Sapienza
SKU: 9786203744866
Price: 4432.0 INR
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by Nihar Ranjan Kar

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ISBN13: 9786203744866
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: May 29, 2021
Pages: 64
Original Price: GBP 35.0
Language: Italian
Edition: N/A
Item Weight: 100 grams
BISAC Subject(s): Pharmacology

About The Book

Nella ricerca e nello sviluppo di sistemi di somministrazione orale di farmaci a velocit� controllata, negli ultimi anni sono stati fatti progressi scientifici e tecnologici superando le avversit� fisiologiche, come i brevi tempi di residenza gastrica (GRT) e i tempi di svuotamento gastrico irregolari (GET). Diversi metodi, compresi i sistemi di rilascio di farmaci galleggianti (FDDS), noti anche come sistemi idrodinamicamente bilanciati (HBS), sistemi di rigonfiamento ed espansione, sistemi polimerici bioadesivi, sistemi di forma modificata, sistemi ad alta densit� e altri dispositivi a svuotamento gastrico ritardato, sono attualmente utilizzati nel prolungamento del GRT. Le varie strategie utilizzate nello sviluppo di FDDS costruendo il meccanismo di galleggiamento basato sulla forma effervescente e non effervescente delle compresse galleggianti. FDDS � un metodo di consegna di farmaci localmente attivi con una piccola finestra di assorbimento nel tratto gastrointestinale superiore, instabile nell'ambiente intestinale inferiore, e con valori di pH pi� alti che hanno una bassa solubilit�. I recenti progressi nei sistemi di consegna dei farmaci galleggianti includono variabili fisiologiche e di formulazione che influenzano il tempo di ritenzione gastrica, approcci alla formulazione di sistemi galleggianti per unit� singole e unit� multiple.

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