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Studio sul comportamento cromatografico degli alcaloidi del papavero da oppio by Jelena Acevska, Gjoshe Stefkov, Aneta Dimitrovska

Studio sul comportamento cromatografico degli alcaloidi del papavero da oppio

by Jelena Acevska , Gjoshe Stefkov , Aneta Dimitrovska
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Book cover type: Paperback
  • ISBN13: 9786209526633
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 108
  • Original Price: GBP 52.98
  • Language: Italian
  • Edition: N/A
  • Item Weight: 155 grams
  • BISAC Subject(s): Pharmacology

L'interesse eccessivo e in continua crescita per la determinazione simultanea degli alcaloidi del papavero da oppio impone lo sviluppo e l'ottimizzazione di metodi convenienti ad alta produttivit� per la valutazione del profilo qualitativo e quantitativo degli alcaloidi nella paglia di papavero. L'ottimizzazione sistematica di diversi metodi cromatografici (GC/FID/MS, RP-HPLC/DAD, Si-HILIC/DAD e ZIC-HILIC/DAD) per la separazione dei principali alcaloidi (morfina, codeina, tebaina, oripavina, papaverina e noscapina) presenti nella paglia di papavero da oppio (Papaver somniferum L., Papaveraceae) � stata effettuata utilizzando il Design of Experiments. Ottimizzando i metodi in modo razionale, � stato possibile evitare una grande quantit� di lavoro di ricerca di laboratorio eccessivo e improduttivo. I metodi sviluppati sono stati convalidati e confrontati in base al potere risolutivo, alla sensibilit�, all'accuratezza, alla velocit�, al costo, agli aspetti ecologici e alla compatibilit� con la procedura di estrazione della paglia di papavero. I metodi proposti forniscono sia uno screening rapido che una valutazione accurata del contenuto degli alcaloidi nei campioni di papavero ottenuti dal programma di selezione delle variet� di Papaver.

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