Tolleranza anziché repressione: Strategie di vaccinazione inverse e cambiamento di paradigma nella strategia di vaccinazione
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Da decenni il sistema immunitario � considerato un obiettivo da attivare o sopprimere. I vaccini hanno lo scopo di rafforzarlo, mentre gli immunosoppressori di rallentarlo. Ma cosa succede se la malattia non deriva da un eccesso o da una carenza di immunit�, bens� da un ricordo errato? La vaccinazione inversa rappresenta un cambiamento di paradigma fondamentale nell'immunoterapia. Invece di bloccare l'infiammazione in modo generalizzato o di indebolire il sistema immunitario a livello globale, questo approccio persegue un obiettivo pi� preciso: il ripristino mirato della tolleranza immunologica nei confronti di antigeni chiaramente definiti. Non soppressione, ma rieducazione. Non effetti a breve termine, ma una modifica sostenibile della malattia. Questo libro ripercorre lo sviluppo scientifico dei vaccini inversi, dalle basi immunologiche ai modelli preclinici fino alle prime applicazioni cliniche. Mostra perch� malattie come la celiachia, la sclerosi multipla o le allergie alimentari fungono da campi di prova, quale ruolo svolgono le analisi multi-omiche, le cellule T regolatorie e la tolleranza specifica per organo, in particolare nel fegato, e perch� le terapie geniche senza strategie basate sulla tolleranza raggiungono i loro limiti a lungo termine. Particolare attenzione � rivolta alle sfide normative, metodologiche e concettuali di questo nuovo principio attivo. I vaccini inversi non rientrano nelle categorie esistenti, ed � proprio qui che risiede il loro potenziale. Costringono la ricerca, la clinica e le autorit� di regolamentazione a considerare l'effetto immunitario non pi� come un effetto a breve termine, ma come uno stato modificabile del sistema. Bremen University Press ha pubblicato oltre 5.500 libri specialistici dal 2005. Gennaio 2026
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