Trapianto di cellule nel trattamento delle lesioni del midollo spinale
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In questo libro, sulla base della nostra esperienza, descriviamo i fondamenti preclinici del trapianto cellulare nel midollo spinale lesionato e i risultati clinici che oggi � possibile ottenere utilizzando cellule staminali mesenchimali (MSC) autologhe del midollo osseo. Nel 2004 abbiamo dimostrato per la prima volta i benefici del trapianto locale di MSC in roditori con lesione del midollo spinale (SCI) completa e cronica. La difficolt� di mantenere in vita a lungo termine animali con SCI completa e la necessit� di confermare nei mammiferi superiori i risultati ottenuti nei roditori ha richiesto pi� di 10 anni di ricerca preclinica prima di applicare queste nuove tecniche agli esseri umani in un'ottica di biosicurezza ed efficacia. Sebbene non siamo ancora in grado di curare un paziente paraplegico, la terapia cellulare con MSC autologhe si configura attualmente come la migliore opzione e offre una nuova speranza ai pazienti affetti da lesione del midollo spinale (SCI), migliorandone la qualit� della vita. Nei prossimi anni, il perfezionamento di queste tecniche, una migliore conoscenza del loro meccanismo d'azione e un'adeguata selezione dei pazienti cambieranno il concetto di irreversibilit� della paraplegia traumatica.
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