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Wechselwirkungen zwischen Neuroektoderm und Primitivstreifen und Kupferkatalyse by Bhanu Iyengar

Wechselwirkungen zwischen Neuroektoderm und Primitivstreifen und Kupferkatalyse

by Bhanu Iyengar
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Book cover type: Paperback
  • ISBN13: 9786209500527
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 212
  • Original Price: GBP 73.86
  • Language: German
  • Edition: N/A
  • Item Weight: 291 grams
  • BISAC Subject(s): General

Embryogenese und Karzinogenese sind Prozesse, die mit einer raschen Proliferation und schnellen Ver�nderungen in der Differenzierung einhergehen. Die Embryogenese ist ein geordneter, programmierter Prozess, der letztendlich zur Entstehung des vollst�ndigen Organismus f�hrt. Im v�lligen Gegensatz dazu ist Krebs formlos, asymmetrisch und unausgewogen, vergleichbar mit einer fehlerhaften Embryogenese. Diese beiden sehr �hnlichen Prozesse lassen sich am besten gemeinsam untersuchen, um die m�glichen Schritte aufzudecken, die zu solch drastisch unterschiedlichen Ergebnissen f�hren. Vor diesem Hintergrund folgt auf eine �bersicht �ber Arbeiten zu Tumoren, in denen die Bedeutung der Induktion und der Zellinteraktionen hervorgehoben wird, eine Untersuchung der Wirkung von Kupfer auf Zellsysteme angesichts der hohen Kupferkonzentrationen in b�sartigen Tumoren. Die vorliegende Studie nutzt das Blastoderm des K�kens als schnell proliferierendes In-vivo-Organkultursystem mit aktiver Zellinteraktion als Modell f�r den Vergleich mit der Onkogenese. Die Arbeit unterstreicht die Tatsache, dass die grundlegenden Zellprozesse in der Embryogenese und Onkogenese gemeinsam sind und dass das Blastoderm des K�kens gewinnbringend als Organkulturmodell f�r die Untersuchung von Proliferation und Differenzierung verwendet werden kann. Hohe Kupferkonzentrationen spielen eine entscheidende Rolle bei der Onkogenese und bei der Blockierung der Wirkung verschiedener antimitotischer Wirkstoffe.

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