La mémoire déclarative dans la schizophrénie
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Les fonctions cognitives sont �troitement li�es au fonctionnement de zones sp�cifiques, de voies neuronales ou de r�seaux corticaux dans les couches sous-jacentes du substrat c�r�bral de la matrice neurologique, au niveau cellulaire et mol�culaire. Les personnes schizophr�nes pr�sentent �galement un large �ventail de troubles cognitifs, notamment des d�ficits au niveau de l'attention, du traitement de l'information, des fonctions ex�cutives, de la m�moire et des capacit�s linguistiques. Les troubles de l'attention et de la m�moire verbale sont consid�r�s comme des marqueurs de vuln�rabilit�, qui peuvent s'av�rer utiles pour d�finir le ph�notype de la schizophr�nie, �tre applicables au d�pistage pr�coce et servir de base � l'�laboration de nouveaux mod�les pour le d�veloppement de traitements. L'objectif de la pr�sente �tude �tait d'�valuer la m�moire d�clarative � l'aide du test PART, bas� sur les stimuli du WCST, chez des patients atteints de schizophr�nie parano�de et indiff�renci�e. Les r�sultats ont montr� que les fonctions ex�cutives et la m�moire d�clarative des schizophr�nes sont alt�r�es par rapport � celles des sujets sains. Au sein des sous-groupes de schizophr�nes, c'est chez les schizophr�nes indiff�renci�s que l'alt�ration est la plus importante.
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