Name: A Guide To Sample Size For Animal-Based Studies
Brand: Wiley
SKU: 9781119799979
Price: 4271.0 INR
Availability: InStock

A Guide To Sample Size For Animal-Based Studies

by Reynolds , Penny S.

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ISBN13: 9781119799979
Binding: Paperback
Subject: Bio-Science and Agriculture
Publisher: Wiley
Publisher Imprint: Wiley
Publication Date: January 1, 2023
Pages: 306
Original Price: USD 71.95
Language: English
Edition: N/A
Item Weight: 676 grams
BISAC Subject(s): Biostatistics, Laboratory Medicine, and Laboratory Techniques

About The Book

From the Back Cover

Understand a foundational area of experimental design with this innovative reference

Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs - Replacement, Reduction and Refinement - the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.

A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "rightsizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.

This book offers:

Step-by-step guidance in diverse methods for approximating and refining sample size
Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
Sample size approximation methods for different types of data - binary, continuous, ordinal, time to event - and different study types - description, comparison, nested designs, reference interval construction and dose-response studies
Numerous worked examples, using real data from published papers, together with SAS and R code

A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

About The Author

Penny S. Reynolds, PhD, is a Research Assistant Professor in the Department of Anesthesiology, College of Medicine, and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, USA.

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