• ISBN13: 9781786390394
• Binding: Hardcover
• Subject: Medical, Nursing and Health SciencesBio-Science and Agriculture
• Publisher: CABI
• Publisher Imprint: CABI
• Publication Date: August 12, 2017
• Pages: 268
• Original Price: 118.55 GBP
• Language: English
• Edition: N/A
• Item Weight: 908 grams

Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide. Harnessing and creating AMPs synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. This new edition lays the foundations for studying AMPs, including a discovery timeline, terminology, nomenclature and classifications. It covers current advances in AMP research and examines state-of-the-art technologies such as bioinformatics, combinatorial libraries, high-throughput screening, database-guided identification, genomics and proteomics-based prediction, and structure-based design of AMPs. Thoroughly updated and revised, this second edition contains new content covering: defensins; cathelicidins; anti-MRSA, antifungal, antiviral, anticancer and antibiofilm strategies; combined treatments; adjuvants in vaccines; advances in AMP technologies that cover surface coating to prevent biofilm formation; nanofiber encapsulation technologies for delivery and sustained release; and understanding innate immunity and the basis for immune boosting to overcome obstacles in developing AMPs into therapeutic agents. Written and reviewed by a group of established investigators in the field, Antimicrobial Peptides is a valuable resource for postgraduate students, researchers, educators, and medical and industrial personnel.

- Dr. Guangshun Wang is an associate professor in the Department of Pathology and Microbiology at the University of Nebraska Medical Center (UNMC), Omaha, USA. He obtained his Ph.D. in Biophysical Chemistry from Simon Fraser University, Canada in 1997. During his postdoctoral stints at the Florida State University and at the National Institutes of Health (USA), he studied 3D structures of bacterial signal-transducing protein-protein complexes by multidimensional NMR spectroscopy. His current research interests at UNMC include structural, bioinformatic, and functional studies of host defense antimicrobial peptides and their potential applications that benefit human beings and agriculture, including both plants and animals. For this purpose, his laboratory created in 2003, and has been maintaining, the Antimicrobial Peptide Database (http://aps.unmc.edu/AP), a widely utilized tool for research and education in the field. Dr. Wang has edited three books, obtained four patents and published 90 original papers, review articles, and book chapters. Currently, he also serves as an Associate Editor for Current Organic Chemistry and an editorial board member of Pharmaceuticals.