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Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development by Ayman F. El-Kattan, Mike S. Lee

Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

by Ayman F. El-Kattan , Mike S. Lee
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Book cover type: Hardcover
  • ISBN13: 9781118916698
  • Binding: Hardcover
  • Subject: Chemistry
  • Publisher: Wiley
  • Publisher Imprint: Wiley
  • Publication Date:
  • Pages: 448
  • Original Price: USD 187.95
  • Language: English
  • Edition: N/A
  • Item Weight: 772 grams
  • BISAC Subject(s): Pharmacology, Chemistry / Toxicology, and Chemistry / Analytic

From the Back Cover

Poor oral bioavailability is one of the leading causes of compound attrition and failure in preclinical and clinical development. In pharmacokinetics, oral bioavailability describes the fraction of an administered dose of a drug that reaches the systemic circulation following oral dosing. It is one of the essential parameters, as bioavailability must be considered when calculating oral doses needed to increase probability of testing the biological mechanism in humans. Since drug developability has become an important criterion to measure the success of scientists working in drug companies, understanding and testing a drug candidate's oral bioavailability is a critical step in the development process.

Specifically geared to personnel in the pharmaceutical and biotechnology industries, Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. The book emphasizes the impact of drug transporters on drug absorption and practices for addressing bioavailability problems. The author includes tutorials for applying these strategies to medicinal chemistry for hit selection, lead optimization, and development candidate selection.

Writing from extensive experience in drug discovery and development, giving short courses on the topic, the author presents the material in an accessible and practical manner that:

  • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
  • Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is underappreciated and complicated area of drug development
  • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
  • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

AYMAN F. EL-KATTAN, B. Pharm, PhD, is Associate Research Fellow in Pfizer's Pharmacokinetics, Dynamics, and Metabolism Department, Cambridge Laboratories and an Adjunct Professor at College of Pharmacy-University of Rhode Island in Rhode Island, US. Dr. El-Kattan is a reviewer for several journals and is an active member of the American Association of Pharmaceutical Scientists (AAPS). He serves on the executive committee of the Drug Transporter focus group. He has been invited speaker 50 times at national/international conferences and has published over 100 papers in peer-reviewed Journals, book chapters, and proceedings.

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