Auswirkungen von endokrinen Disruptoren auf das männliche Fortpflanzungssystem
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Chemikalien, die als endokrine Disruptoren wirken, sind in der Umwelt vorhanden und besitzen antiandrogene und/oder �strogen�hnliche Eigenschaften, die sch�dliche Auswirkungen auf das m�nnliche Fortpflanzungssystem haben und zu Unfruchtbarkeit sowie erektiler Dysfunktion (ED) f�hren. Diese �strogen�hnlichen oder antiandrogenen Chemikalien werden als endokrine Disruptoren bezeichnet, da sie entweder die Struktur nat�rlicher Hormone nachahmen, die Wirkung der Hormone hemmen oder Ver�nderungen in der normalen Hormonregulation des endokrinen Systems hervorrufen. Viele Pestizide mit endokrinen Disruptoren-Eigenschaften sind daf�r bekannt, die Fortpflanzungsf�higkeit von M�nnern und Frauen zu beeintr�chtigen. Pestizide gelten als eine �u erst vielf�ltige Gruppe von Verbindungen und stellen eine der wichtigsten Gruppen chemischer Stressoren in der Umwelt dar. Der Gro teil der menschlichen Bev�lkerung ist diesen Schadstoffen in der allgemeinen Umwelt oder an ihren Arbeitspl�tzen ausgesetzt. Die heute verwendeten chemischen Insektizide sind Neurotoxine und wirken, indem sie das Nervensystem der Zielorganismen zerst�ren. Pestizide, die als endokrine Disruptoren wirken, beeintr�chtigen das m�nnliche Fortpflanzungssystem, indem sie die endokrinologische Hom�ostase st�ren.
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