Biomarqueurs de l'ovulation dans la salive
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Cette th�se de doctorat �tudie comment la salive peut �tre utilis�e comme un outil simple et non invasif pour d�tecter l'ovulation chez l'homme. La salive contient de nombreuses biomol�cules importantes, en particulier des prot�ines, qui refl�tent les changements dans le corps au cours du cycle menstruel. Dans cette �tude, les propri�t�s physiques, chimiques et ultrastructurelles de la salive ont �t� examin�es au cours de diff�rentes phases du cycle, r�v�lant des variations �videntes. En utilisant des techniques prot�omiques avanc�es, l'�tude a identifi� des changements significatifs dans l'expression des prot�ines, avec plus de 530 prot�ines d�tect�es pendant la phase d'ovulation, contre moins dans les autres phases. Des prot�ines cl�s telles que la cystatine-S, la prot�ine inductible � la prolactine et l'anhydrase carbonique 6 se sont r�v�l�es �tre fortement exprim�es pendant l'ovulation. Les r�sultats sugg�rent que la d�tection de l'ovulation � partir de la salive pourrait faciliter les traitements de fertilit� et la planification familiale naturelle. Cette recherche ouvre la voie au d�veloppement de biocapteurs faciles et sans stress pour une pr�diction pr�cise de l'ovulation.
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