Cardiorespiratory Aspects of Duchenne Muscular Dystrophy: New Perspectives and Controversies

Name: Cardiorespiratory Aspects of Duchenne Muscular Dystrophy: New Perspectives and Controversies
Brand: Academic Press
SKU: 9780443415982
Price: 16830.0 INR
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by David J. Birnkrant

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ISBN13: 9780443415982
Binding: Paperback
Subject: N/A
Publisher: Academic Press
Publisher Imprint: Academic Press
Publication Date: May 28, 2026
Pages: 200
Original Price: USD 175.0
Language: English
Edition: N/A
Item Weight: 540 grams
BISAC Subject(s): Life Sciences / Biology

About The Book

Cardiorespiratory Aspects of Duchenne Muscular Dystrophy: New Perspectives and Controversies is designed to address key challenges in the field by providing a cardiorespiratory perspective on clinical care, drug development, and the regulatory approval of new drugs. The book discusses current achievements and limitations of care and addresses clinical challenges. It offers a detailed, critical examination of the drug development process and identifies potential flaws in current regulatory processes. Novel recommendations for improving study methodologies and regulatory decisions are discussed, with the goal of enabling more effective drugs to reach individuals with Duchenne Muscular Dystrophy (DMD).
This book is designed to provide important and interesting information to a variety of stakeholders, including clinicians, researchers, and regulators, as well as patients and their caregivers. Clinicians will find a summary of standards of care and strategies to overcome the challenges they are likely to face in enacting those standards. Researchers will gain insights into the crucial importance of cardiorespiratory outcome measures and find recommendations designed to improve study methodologies. Regulators will benefit from an examination of potential flaws in the current drug approval process and from proposed recommendations aimed at ensuring that approved drugs are truly effective. The goal of this comprehensive approach is to enhance the outcomes and survival of individuals with DMD by focusing on key determinants of cardiorespiratory health.

About The Author

Birnkrant, David J.: - Dr. Birnkrant is Professor Emeritus of Pediatrics at Case Western Reserve University School of Medicine and a board-certified clinician in pediatric pulmonology and sleep medicine.

With over 25 years in the pediatric neuromuscular clinic, he has dedicated his career to caring for individuals with neuromuscular diseases, particularly focusing on the cardiorespiratory management of Duchenne muscular dystrophy (DMD).

He has developed patents for respiratory devices to improve ventilatory assistance and has published extensively on DMD, emphasizing survival prolongation, anesthetic management, noninvasive ventilation, new drug therapies, and cardiorespiratory phenotypic variability.

His recent work critiques DMD drug study methodologies and regulatory pathways. Dr. Birnkrant was the lead author of the 2018 "Care Considerations for Duchenne Muscular Dystrophy" in The Lancet Neurology, now a standard of care.

He serves on the Editorial Board of Pediatric Pulmonology, has consulted for the FDA, and is the 2024 recipient of the Margaret Pfrommer Endowed Memorial Lecture award in home-based mechanical ventilation.

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