Czy zmiany w acetylacji bialek SR mogą wplywac na alternatywne splicowanie?

Name: Czy zmiany w acetylacji bialek SR mogą wplywac na alternatywne splicowanie?
Brand: Wydawnictwo Nasza Wiedza
SKU: 9786630074451
Price: 5442.0 INR
Availability: InStock

by Heather E. Knupp

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ISBN13: 9786630074451
Binding: Paperback
Subject: N/A
Publisher: Wydawnictwo Nasza Wiedza
Publisher Imprint: Wydawnictwo Nasza Wiedza
Publication Date: May 18, 2026
Pages: 64
Original Price: GBP 43.0
Language: Polish
Edition: N/A
Item Weight: 100 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Fenotyp i funkcja kom�rki są determinowane przez proteom kom�rkowy. W obrębie proteomu kom�rkowego zachodzą procesy, kt�re mogą znacząco zmienic jego sklad. Jednym z takich proces�w jest tzw. alternatywne splicowanie. Splicowanie polega na usuwaniu intron�w z sekwencji pre-mRNA, a pozostale fragmenty pre-mRNA, zwane eksonami, są lączone. Splicing alternatywny modyfikuje kombinację intron�w i ekson�w i może tworzyc nowe produkty z r�żnych uklad�w sekwencji kodujących. Nieprawidlowa regulacja splicingu alternatywnego zostala udokumentowana w wielu chorobach czlowieka. Regulacja splicingu alternatywnego obejmuje zlożoną siec bialek i RNA. Bialka z powt�rzeniami seryny i argininy (SR) to znana rodzina bialek regulacyjnych, kt�re wiążą się w obrębie ekson�w, aby sprzyjac wlączeniu ekson�w do dojrzalego transkryptu mRNA. Aktywnośc bialek SR jest regulowana przez modyfikacje potranslacyjne, fosforylację i acetylację. Przedstawione badanie proponuje możliwy mechanizm, w jaki acetylacja bialek SR może wplywac na alternatywne splicowanie. Niniejsza publikacja powinna byc pomocna dla wszystkich os�b zainteresowanych regulacją alternatywnego splicingu i bialkami SR.

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